4.7 Article

Rapid Detection of Powassan Virus in a Patient With Encephalitis by Metagenomic Sequencing

Journal

CLINICAL INFECTIOUS DISEASES
Volume 66, Issue 5, Pages 789-792

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cix792

Keywords

Powassan virus; encephalitis; metagenomic sequencing

Funding

  1. National Institutes of Health [KL2 TR001100, T32 AI007061, T32 AG000222]
  2. Massachusetts General Hospital Department of Neurology SPARK Award

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We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.

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