Journal
CHEMICAL REVIEWS
Volume 118, Issue 3, Pages 323-339Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00145
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Funding
- National Institutes of Health (NIH) [R01 GM115188]
- Welch Foundation [I-1561]
- Once Upon a Time... Foundation
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Posttranslational modifications are covalent changes made to proteins that typically alter the function or location of the protein. AMPylation is an emerging posttranslational modification that involves the addition of adenosine monophosphate (AMP) to a protein. Like other, more well-studied posttranslational modifications, AMPylation is predicted to regulate the activity of the modified target proteins. However, the scope of this modification both in bacteria and in eukaryotes remains to be fully determined. In this review, we provide an up to date overview of the known AMPylating enzymes, the regulation of these enzymes, and the effect of this modification on target proteins.
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