Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 42, Pages 23387-23397Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b05520
Keywords
high-aspect ratio; nanostructures; macromolecules; physical delivery; high-throughput
Funding
- NIH [U01 268201000043C-0-0-1, RO1 AI107116-01, RO1 AI088023-03]
- Siebel Scholars Foundation
- WM Keck Foundation
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There is great need for the development of an efficient delivery method of macromolecules, including nucleic acids, proteins, and peptides, to cell cytoplasm without eliciting toxicity or changing cell behavior. High-aspect ratio nanomaterials have addressed many challenges present in conventional methods, such as cell membrane passage and endosomal degradation, and have shown the feasibility of efficient high-throughput macromolecule delivery with minimal perturbation of cells. This review describes the recent advances of in vitro and in vivo physical macromolecule delivery with high-aspect ratio nano-structured materials and summarizes the synthesis methods, material properties, relevant applications, and various potential directions.
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