Journal
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
Volume 50, Issue 4, Pages 550-553Publisher
SOC BRASILEIRA MEDICINA TROPICAL
DOI: 10.1590/0037-8682-0447-2016
Keywords
Tuberculosis; MDR; Nitrate reductase
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Funding
- Minas Gerais State Research Support Foundation (FAPEMIG) [65/10]
- National Council for Scientific and Technological Development [Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)] [310174/2014-7-CNPQ]
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Introduction: This study aimed to evaluate a new commercial kit, Kit SIRE Nitratase-PlastLabor, for testing the drug susceptibility of clinical Mycobacterium tuberculosis isolates. Methods: The accuracy of the Kit SIRE Nitratase was evaluated by examining the susceptibility (streptomycin, isoniazid, rifampicin, and ethambutol) of 40 M. tuberculosis isolates, using the proportion method with Lowenstein-Jensen medium or the BACTEC MGIT 960 system. Results: The detection accuracy for streptomycin, isoniazid, rifampicin, and ethambutol was 95%, 97.5%, 100%, and 80%, respectively. Conclusions: The exceptional accuracy demonstrated by Kit SIRE Nitratase for isoniazid and rifampicin makes the kit an attractive option for screening M. tuberculosis strain resistance.
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