Journal
LUNG INDIA
Volume 35, Issue 2, Pages 160-163Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/lungindia.lungindia_347_17
Keywords
Acquired resistance; epidermal growth factor receptor; histological transformation; nonsmall cell lung carcinoma; small cell lung carcinoma; tyrosine kinase inhibitor
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A subset of non-small cell lung carcinoma (NSCC) harbor active mutations of epidermal growth factor receptor ( EGFR). In these, EGFR tyrosine kinase inhibitors (EGFR-TKIs) are recommended as the first-line treatment. Though drug resistance is inevitable, histological transformation to small cell lung carcinoma (SCLC) is a rare mechanism for acquired resistance. Here we report one such rare case of histological transformation of pulmonary adenocarcinoma to small cell lung carcinoma in 46 year old male treated with Gefitinib.
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