Journal
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
Volume 27, Issue 3, Pages 302-305Publisher
SOC BRASILEIRA FARMACOGNOSIA
DOI: 10.1016/j.bjp.2017.01.007
Keywords
Cytotoxicity; 19-Deoxyicetexone; 7,20-Dihydroanastomosine; Icetexone; 19-Deoxyisoicetexone; Cell viability
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New compounds with chemotherapeutic activity are sought after, and plants are an important source of these compounds. Four diterpenes, 19-deoxyicetexone, 7,20-dihydroanastomosine, icetexone and 19-deoxyisoicetexone, were isolated from the hexane-washed chloroform extract of Salvia ballotiflora. The cytotoxic activity of the hexane-washed chloroform extract and its four diterpenes were tested using the MTT assay against three tumor cell lines: HeLa (cervical cancer), A549 (lung cancer) and MCF7 (breast cancer), and two murine cell line: J774A.1 (epithelial cancer) and CT26 (colon cancer), and their IC50 values were determined. 19-Deoxyisoicetexone had the greatest effect on HeLa cells with IC50 of 3.2 mu g/ml (9.36 mu M), whereas hexane-washed chloroform extract had the best cytotoxic effect on A549 cells with an IC50 of 2.29 mu g/ml. These effects of 19-deoxyisoicetexone and hexane-washed chloroform extract were with similar activity compared to cisplatin (IC50 = 1.06 mu g/ml in HeLa cells, and 4.6 mu g/ml (15.21 mu M) in A549 cells). (C) 2017 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.
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