Journal
REVIEWS IN ENVIRONMENTAL SCIENCE AND BIO-TECHNOLOGY
Volume 16, Issue 2, Pages 327-345Publisher
SPRINGER
DOI: 10.1007/s11157-017-9431-4
Keywords
Acetic acid; Propionic acid; Butyric acid; Isobutyric acid; Isovaleric acid; Volatile fatty acids
Funding
- National Research Foundation of Korea [NRF-2015R1A2A2A04006014, NRF-2016R1D1A1B03932301, NRF-2015M1A5A1037196]
- Konkuk University, Seoul, South Korea
- National Research Foundation of Korea [2015M1A5A1037196, 2016R1D1A1B03932301, 2015R1A2A2A04006014] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Volatile fatty acids (VFAs) are used as building blocks to synthesize a wide range of commercially-important chemicals. Microbially produced VFAs (acetic acid, propionic acid, butyric acid, isobutyric acid, and isovaleric acid) can be considered as a replacement for petroleum-based VFAs due to their renewability, degradability, and sustainability. The main objective of this review is to summarize research and development of VFA production methods via microbial routes, their downstream processes, current applications, and main challenges. Various fermentation processes have been developed to produce of VFAs starting from commercially-available sugars and other raw materials such as lignocellulose, whey, and waste sludge. Only few microbes have been explored for their potential to produce VFAs, and very little genomic information data is available at the present time. There is a need to use metabolic engineering, systematic biology, evolutionary engineering, and bioinformatics to discover VFA biosynthesis routes since the pathways for isobutyric acid and isovaleric acids are still not well understood.
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