Journal
ENVIRONMENTAL RESEARCH
Volume 136, Issue -, Pages 57-66Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2014.10.009
Keywords
Environmental monitoring; House dust; Organochlorine pesticides; Polybrominated diphenyl ethers; Polychlorinated biphenyls
Funding
- National Institute of Environmental Health Sciences (NIEHS) [R01E5009137, R01ES015899, P42ESO470518, P01 ES018172]
- Intramural Research Program of the National Cancer Institute (NCI)
- National Institutes of Health [7590-S-04, 7590-S-01]
- NCI [NO2-CP-11015]
- U.S. Environmental Protection Agency (EPA) [RD83451101]
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Background: Humans are exposed to persistent organic pollutants (POPs) through various routes, including consumption of contaminated food and accidental ingestion of settled dust. Objectives: We aimed to identify key routes of exposure to organochlorine pesticides, polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs) in California women of reproductive age. Methods: Blood was collected from 48 mothers participating in the California Childhood Leukemia Study from 2006 to 2007 and analyzed for POPs using gas chromatography-mass spectrometry. Multivariable linear regression models of natural-log transformed serum concentrations were used to identify determinants of exposure from available questionnaire information on dietary habits, reproductive history, and demographic characteristics, as well as vacuum cleaner dust-POP levels. Results: After adjusting for blood lipid levels, age, body mass index, cumulative lactation, and sampling date, serum concentrations of multiple major PCBs were positively associated with fish consumption, but not dust-PCB levels. After adjusting for blood lipid levels, Hispanic ethnicity, country of origin, and household annual income, serum concentrations of multiple major PBDEs were positively associated with dust-PBDE levels. Conclusions: Our findings suggest that the relative contribution of specific exposure routes to total POP intake varies by chemical class, with dust being a relatively important source of PBDEs and diet being a relatively important source of PCBs. (C) 2014 Elsevier Inc. All rights reserved.
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