Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume 58, Issue 5, Pages 741-754Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2016.1220914
Keywords
C. elegans; living model; obesity; aging
Categories
Funding
- National Institute of Food and Agriculture
- U.S. Department of Agriculture
- Massachusetts Agricultural Experiment Station
- Department of Food Science, the University of Massachusetts Amherst [MAS00450]
- China Scholarship Council
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Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively utilized as an animal model for research involving aging and neurodegenerative diseases, like Alzheimer's and Parkinson's, etc. Compared with traditional animal models, this small nematode possesses many benefits, such as small body size, short lifespan, completely sequenced genome, and more than 65% of the genes associated with human disease. All these characteristics make this organism an ideal living system for obesity and aging studies. This review gives a brief introduction of C. elegans as an animal model, highlights some advantages of research using this model and describes methods to evaluate the effect of treatments on obesity and aging of this organism.
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