Journal
AUTOPHAGY
Volume 14, Issue 1, Pages 3-21Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2017.1384887
Keywords
autophagy; calcium; chloride; ion channels; potassium; sodium
Categories
Funding
- INSERM
- INCA
- Region Nord/Pas-de-Calais
- SIRIC ONCOLille
- National Institutes of Health [GM053396]
- FRABio
- la Ligue Nationale Contre le Cancer
- Ministere de l'Education Nationale
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Autophagy is a cellular process in which the cell degrades and recycles its own constituents. Given the crucial role of autophagy in physiology, deregulation of autophagic machinery is associated with various diseases. Hence, a thorough understanding of autophagy regulatory mechanisms is crucially important for the elaboration of efficient treatments for different diseases. Recently, ion channels, mediating ion fluxes across cellular membranes, have emerged as important regulators of both basal and induced autophagy. However, the mechanisms by which specific ion channels regulate autophagy are still poorly understood, thus underscoring the need for further research in this field. Here we discuss the involvement of major types of ion channels in autophagy regulation.
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