Journal
COGNITIVE NEURODYNAMICS
Volume 12, Issue 2, Pages 211-223Publisher
SPRINGER
DOI: 10.1007/s11571-017-9468-7
Keywords
Epileptogenesis; Limbic system; Power spectral analysis; Phase diagram; Autocorrelation; Chaotic attractors; Limit cycles
Categories
Ask authors/readers for more resources
Simulations of EEG data provide the understanding of how the limbic system exhibits normal and abnormal states of the electrical activity of the brain. While brain activity exhibits a type of homeostasis of excitatory and inhibitory mesoscopic neuron behavior, abnormal neural firings found in the seizure state exhibits brain instability due to runaway oscillatory entrained neural behavior. We utilize a model of mesoscopic brain activity, the KIV model, where each network represents the areas of the limbic system, i.e., hippocampus, sensory cortex, and the amygdala. Our model initially demonstrates oscillatory entrained neural behavior as the epileptogenesis, and then by increasing the external weights that join the three networks that represent the areas of the limbic system, seizure activity entrains the entire system. By introducing an external signal into the model, simulating external electrical titration therapy, the modeled seizure behavior can be 'rebalanced' back to its normal state.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available