Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 245, Issue -, Pages 65-75Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2016.11.001
Keywords
Prevalence of sleep disordered breathing; Chemoreflex properties; Respiratory plasticity; Testosterone; Estrogen; Progesterone
Categories
Funding
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development [15SRCS003, 101CX000125-JHM]
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The prevalence of sleep disordered breathing is greater in men compared to women. This disparity could be due to sex differences in the diagnosis and presentation of sleep apnea, and the pathophysiological mechanisms that instigate this disorder. Women tend to report more non-typical symptoms of sleep apnea compared to men, and the presentation of apneic events are more prevalent in rapid compared to non-rapid eye movement sleep. In addition, there is evidence of sex differences in upper airway structure and mechanics and in neural mechanisms that impact on the control of breathing. The purpose of this review is to summarize the literature that addresses sex differences in sleep-disordered breathing, and to discuss the influence that upper airway mechanics, chemoreflex properties, and sex hormones have in modulating breathing during sleep in men and women. Published by Elsevier B.V.
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