Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 242, Issue -, Pages 80-85Publisher
ELSEVIER
DOI: 10.1016/j.resp.2017.04.001
Keywords
Glycerol; Lung mechanics; Lung morphometry; Bronchoreactivity
Categories
Funding
- Brazilian Council for Scientific and Technological Development (MCT/CNPq
- Coordination for the Improvement of Higher Education Personnel (CAPES)
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The combustion of residual glycerol to generate heat in industrial processes has been suggested as a cost-effective solution for disposal of this environmental liability. Thus, we investigated the effects of exposure to the exhaust gases of glycerol combustion in the rat respiratory system. We used 2 rats groups, one exposed to the exhaust gases from glycerol combustion (Glycerol), and the other exposed to ambient air (Control). Exposure occurred 5 h a day, 5 days a week for 13 weeks. We observed statistically changes in all parameters of respiratory system mechanics in vivo. This results was supported by histological analysis and morphometric data, confirming narrower airways and lung parenchimal changes. Variables related to airway resistance (Delta R-N) and elastic properties of the tissue (Delta H), increased after challenge with methacholine. Finally, analysis of lung tissue micromechanics showed statistically increases in all parameters (R, E and hysteresivity). In conclusion, exhaust gases from glycerol combustion were harmful to the respiratory system.
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