Journal
RESPIRATORY MEDICINE
Volume 132, Issue -, Pages 112-116Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2017.10.004
Keywords
Asthma; Cohort study; Endometriosis; Epidemiology; National Health Insurance Research Database
Funding
- Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence [MOHW106-TDU-B-212-113004]
- China Medical University Hospital, Taichung, Taiwan
- Academia Sinica Taiwan Biobank Stroke Biosignature Project [BM10601010036]
- Taiwan Clinical Trial Consortium for Stroke [MOST 106-2321-B-039-005]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Taiwan Brain Disease Foundation, Taipei, Taiwan
- China Medical University, Taichung, Taiwan [CMU104-S-46]
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
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Background: Evidence regarding the association between asthma and endometriosis is limited and inconsistent. The goal of the study was to investigate whether women diagnosed as having asthma were at a greater risk of endometriosis than age-matched unaffected women. Methods: We conducted a nationwide population-based retrospective study by using data retrieved from the Taiwan National Health Insurance Research Database during the period of 2000-2005 with follow-up through 2013. The current analysis included 7337 women aged 12-50 years with newly diagnosed asthma and using asthma-related medications and 29,348 age-matched women without asthma. A Cox proportional hazards regression model was used to estimate the risks of endometriosis in women with asthma as compared with those without asthma. Results: The overall risk of endometriosis in the asthma group was 1.50-fold higher (95% confidence interval = 1.33-1.70) than that in the nonasthma group. A stratified analysis by age further revealed that patients with asthma were associated with a higher risk of endometriosis in age groups of 21-50 years. Conclusion: Compared with women without asthma, women with asthma of reproductive age are at a higher risk of endometriosis. Additional studies are warranted to elucidate the mechanism(s) underlying the association between asthma and a higher risk of endometriosis.
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