Journal
ENVIRONMENTAL POLLUTION
Volume 196, Issue -, Pages 185-193Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2014.09.020
Keywords
Nano-TiO2; 2,3,7,8-TCDD; CYP1A; Immunomodulation; Genotoxicity
Categories
Funding
- Italian Ministry of Research [PRIN2009FHHP2W]
- Ministry of Education of the Czech Republic [LM2011028]
- CETOCOEN project of the European Structural Funds [CZ.1.05/2.100/01.001]
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The present study investigated the influence of nano-TiO2 (1 mg L-1) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (46 pg L-1) bioconcentration and toxicity in the European sea bass (Dicentrarchus labrax) during 7 days in vivo exposure. A multimarkers approach was applied in different organs: detoxification in liver; innate immunity and pro-inflammatory response and adaptive immunity in gills and spleen; genotoxicity in peripheral erythrocytes and muscle. Bioconcentration of 2,3,7,8-TCDD in presence of nano-TiO2 was investigated in liver, skin and muscle as well as interaction between nanoTiO(2) and organic pollutants in artificial sea water (ASW). Nano-TiO2 negatively influenced immune response induced by 2,3,7,8-TCDD in spleen but not in gills and reduced the DNA damage induced by 2,3,7,8-TCDD in erythrocytes. nano-TiO2 did not interfere with 2,3,7,8-TCDD detoxification and bioconcentration according to the observed no interaction of the nano-TiO2 with organic pollutants in ASW. (C) 2014 Elsevier Ltd. All rights reserved.
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