Journal
RESEARCH ON CHEMICAL INTERMEDIATES
Volume 43, Issue 11, Pages 6691-6700Publisher
SPRINGER
DOI: 10.1007/s11164-017-3015-3
Keywords
EDTA-4Na; Chromenes; Multicomponent reaction; Atom economy
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An efficient and practical protocol for the synthesis of chromenes derivatives catalyzed by a low-loading sodium ethylene diamine tetraacetate (2 mol%) as a catalyst via multicomponent reaction is reported. A wide range of aromatic aldehydes easily undergo condensations with malononitrile and 4-hydroxycoumarin (4-hydroxy-6-methyl-2-pyrone or dimedone) under mild conditions to afford the desired products of good purity in excellent yields. This protocol has several advantages, such as mild conditions, high yields, and an inexpensive catalyzed system.
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