Journal
RESEARCH IN MICROBIOLOGY
Volume 169, Issue 7-8, Pages 425-431Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2017.10.005
Keywords
AcrAB-TolC; Transcription; Induction; Multidrug resistance; Salmonella; Escherichia coli
Categories
Funding
- MRC [G0801977, G0501415] Funding Source: UKRI
- Medical Research Council [G0501415, G0801977] Funding Source: Medline
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Bacterial multidrug efflux systems are a major mechanism of antimicrobial resistance and are fundamental to the physiology of Gram-negative bacteria. The resistance-nodulation-division (RND) family of efflux pumps is the most clinically significant, as it is associated with multidrug resistance. Expression of efflux systems is subject to multiple levels of regulation, involving local and global transcriptional regulation as well as post-transcriptional and post-translational regulation. The best-characterised RND system is AcrAB-TolC, which is present in Enterobacteriaceae. This review describes the current knowledge and new data about the regulation of the acrAB and tolC genes in Escherichia coli and Salmonella enterica. (C) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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