Journal
REPRODUCTIVE TOXICOLOGY
Volume 71, Issue -, Pages 71-77Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.04.009
Keywords
Diethylstibestrol; Pregnancy loss; First trimester; Congenital birth defects; Cancer
Categories
Funding
- Women and Children Research Institute
- Saudi Cultural Bureau
- Canadian Foundation for Women's Health (CFWH)
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Diethylstilbestrol (DES) was an orally active estrogen prescribed to the pregnant women to prevent miscarriages. DES is known as a 'biological time bomb' and long-term effects of DES have been recorded in the mothers exposed to DES and their offspring (DES-daughters and DES-sons). Adverse pregnancy outcomes, infertility, cancer, and early menopause have been discovered in women exposed to DES, and some events occur in their offspring and subsequent generations. An increased risk of breast cancer is not limited to the DES-exposed daughters. There is an urgent need to find ways to stop the inheritance cycle of DES and prevent adverse effects of DES in the future generations. The present article reviews the health implications of DES exposure and screening exams currently recommended to DES daughters and their offspring. (C) 2017 Elsevier Inc. All rights reserved.
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