Journal
REPRODUCTIVE TOXICOLOGY
Volume 67, Issue -, Pages 149-164Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.01.005
Keywords
Silver nanoparticles; Nanomaterials; Reproductive toxicity; Sperm/testicular toxicity; Developmental toxicity; Developmental neurotoxicity; Placental transfer; Blood-testis barrier
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Funding
- Ministry of Economy, Trade and Industry (METI) of Japan
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We summarized significant effects reported in the literature on the reproductive and developmental toxicity of silver nanoparticles (AgNPs) in laboratory animals. AgNPs showed testicular/sperm toxicity in males and ovarian and embryonic toxicity in females. Maternal injection of AgNPs delayed physical development and impaired cognitive behavior in offspring. Ag was accumulated in the testes after administration of AgNPs. AgNPs were identified in the visceral yolk sac after administration during early gestation in mice. Radiolabeled AgNPs were detected in placenta, breast milk, and pre- and postnatal offspring after injection during late gestation in rats. Ag in the ionic form, and possibly also particles, was suggested to be bioavailable. Although this review provides initial information on the potential reproductive and developmental toxicity of AgNPs, data is still very limited. Further studies using state-of-the-art methodologies and the relevant routes and doses for human exposure are required. (C) 2017 Elsevier Inc. All rights reserved.
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