Journal
REPRODUCTIVE TOXICOLOGY
Volume 68, Issue -, Pages 130-144Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.07.020
Keywords
Bisphenol A (BPA); Obesity; Body composition; Sex differences; Non-monotonic dose response; Extreme hyperactivity; Developmental origins of adult disease
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Funding
- NIEHS [5RC2ES18781, R01 ES08134]
- NIH [CTSA UL1TR001064]
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Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250 mu gBPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response. (C) 2016 Published by Elsevier Inc.
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