Journal
REPRODUCTIVE TOXICOLOGY
Volume 69, Issue -, Pages 204-211Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.03.004
Keywords
Adiponectin; Endocrine disrupting chemicals; Steroidogenesis; Ovarian follicles
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Funding
- Jagiellonian University in Krakow, Poland [K/ZDS/006310]
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We determined the effect of dioxin-like polychlorinated naphtalenes (PCN) (Halowax 1051) (100 pg/ml), benzo(a)pyrene [B(a)P1 (2.5 ng/ml), hexachlorobenzene (HCBz) (0.2 ng/ml) and non-dioxin like poly-brominated diphenyl ether (BDE-47) (25 ng/ml) and bisphenol A (BPA) (20 ng/ml) on ovarian adiponectin secretion (ELISA) and its receptors expression (Western blot). Ovarian cells co-culture was used to examine action of endocrine disruptors (EDCs) on adiponectin (10 mu g/ml) stimulated steroidogenesis. B(a)P, HCBz, testosterone (T) decreased adiponectin secretion and receptors expression, BPA, BDE-47, estradiol (E2) had the opposite effect, while PCN had inhibitory effect only on adiponectin secretion. In adiponectin stimulated cells dioxin-like compounds decreased E2 and except of PCN had no effect on T, while non-dioxin like increased E2 and decreased T secretion. Results indicated to modulatory role of EDCs on adiponectin and its receptor and its action on ovarian steroidogenesis, suggest that dioxin-like compounds may contribute to the ovarian dysfunction in obesity-related disorders. (C) 2017 Elsevier Inc. All rights reserved.
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