Journal
REPRODUCTIVE TOXICOLOGY
Volume 67, Issue -, Pages 117-124Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2016.12.003
Keywords
Di (2-ethylhexyl) phthalate (DEHP); Intrauterine growth restriction (IUGR); Developmental toxicity; Endocrine disrupting chemicals
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Funding
- National Natural Science Foundation of China [81630084, 31000602, 81471467]
- Anhui Provincial Natural Science Foundation [1608085MH218, 1308085QC48]
- Grants for Scientific Research of BSKY from Anhui Medical University [XJ201203]
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Di (2-ethylhexyl) phthalate (DEHP) is male developmental toxicant that impairs testis development with reduced anogenital distance. The present study aimed to investigate whether maternal DEHP exposure during pregnancy causes intrauterine growth restriction (IUGR) in a gender-specific manner and to identify the critical window of DEHP-induced fetal IUGR. Pregnant mice were administered with DEHP (0, 50 or 200 mg/kg) by gavage. Fetal IUGR was observed not only in males but also in females when litters were exposed to DEHP on gestational day (GD)0-GD17. Interestingly, fetal weight and crown-rump length were reduced, markedly in dams with DEHP on GD13-GD17, slightly in dams with on GD7-GD12, but not in dams with on GD0-GD6. Further analysis showed that maternal DEHP exposure on GD7-GD12 inhibited cell proliferation, lowered placental weight, and reduced blood sinusoid area in placental labyrinth layer. These results suggest that maternal DEHP exposure induces IUGR in a stage-specific but gender-independent manner. (C) 2016 Elsevier Inc. All rights reserved.
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