Journal
REPRODUCTIVE TOXICOLOGY
Volume 73, Issue -, Pages 312-321Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.07.004
Keywords
Male fertility; Human serum; DL-PCBs; Semen parameters; Endocrine disruptors
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Funding
- Catedra Human Fertility from the University of Alicante [60931013]
- University of Alicante [VIGROB-186]
- Ministerio Economia y Competitividad [CTQ2013-41006-R]
- Valencian Community Government (Spain) [PROMETEOII/2014/007]
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The relationship between dioxin-like polychlorinated biphenyl (DL-PCB) levels in serum and semen parameters were investigated. Our case-control included two groups of patients. Total concentrations of PCBs were significantly higher in the low semen quality (n = 24) than in the normal semen quality (n = 26) group. A significant negative correlation was found between PCB 126 and viability in men with low semen quality, while PCBs 77 and 81 were positively correlated with morphology, and PCB 118, mono-ortho and total DL-PCBs were positively correlated with volume. In the normal semen quality group, PCB 189 and 118 were negatively correlated with sperm motility and volume, respectively. In addition, positive significant correlations were found between PCB 77, 23 and total non-ortho PCBs with regard to morphology. Our findings suggest that sperm motility, viability, volume and morphology are parameters sensitive to alteration by exposure to DL-PCBs, although PCB effects on spermatogenesis were not of clinical significance. (C) 2017 Elsevier Inc. All rights reserved.
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