Journal
BIOTECHNOLOGY LETTERS
Volume 40, Issue 3, Pages 493-500Publisher
SPRINGER
DOI: 10.1007/s10529-017-2489-9
Keywords
Lin28A; MALAT1; Migration; Osteocarcinoma; RNA; Binding protein
Categories
Ask authors/readers for more resources
To explore the effects of Lin28A on progression of osteocarcinoma (OS) cells. Lin28A mRNA and protein expressions were significantly increased in OS tissues compared with that in normal adjacent tissues. Expressions of Lin28A and long noncoding RNA MALAT1 were positively correlated. Patients with higher Lin28A expression had shorter overall survival. Moreover, Lin28A knockdown inhibited OS cells proliferation, migration, invasion and promoted cell apoptosis; Lin28A was found to harbor binding sites on MALAT1 sequences and associated with MALAT1, and increased MALAT1 stability and expression. Notably, the inhibition of Lin28A knockdown was attenuated or even reversed by MALAT1 overexpression. RNA binding protein Lin28A could facilitate OS cells progression by associating with the long noncoding RNA MALAT1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available