Journal
ACTA BIOCHIMICA POLONICA
Volume 65, Issue 1, Pages 35-41Publisher
ACTA BIOCHIMICA POLONICA
DOI: 10.18388/abp.2016_1387
Keywords
Ginkgo biloba extract; rutin; quercetin; diabetic cataract
Categories
Funding
- National Natural Foundation of China [81473257]
- Jiangsu Six Talent Peaks Foundation of China [2011-SWYY-019]
- Graduate Research and Innovation Plan of Jiangsu Province [CXZZ13-0997]
- Director Foundation of Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy [ZR-XY201503]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Ask authors/readers for more resources
One of the earliest critical secondary complications of diabetes is the opacification of the eye lens - a condition strictly associated with diabetic cataract. The study presented here was designed to investigate the effect of Ginkgo biloba extract (GbE), rutin and quercetin on streptozotocin (STZ) induced diabetic cataract (DC) rats. Ten weeks after administration of GbE, rutin and quercetin, the opacity of diabetic rats' lenses was graded under a slit lamp. Then, the levels of malondialdehyde (MDA), reduced glutathione (GSH), advanced glycosylation end products (AGEs), and the activities of aldose reductase (AR) were estimated. The DC-induced rats produced less GSH, higher levels of MDA and AGEs as well as elevated AR activity when compared to the normal group. Administration of GbE, rutin and quercetin remarkably inhibited the AR activity, stimulated the production of glutathione, and decreased the levels of MDA and AGEs in the lenses of DC-induced rats, which eventually delayed the progression of lens opacification in diabetic rats to various degrees. Our results revealed that quercetin had the highest significant (P<0.05) potential to delay the progression of STZ-induced diabetic cataract when compared with rutin and GbE. The mechanism dictating this interesting prowess of quercetin might be attributed to its AR inhibitory strength, anti-lipid peroxidation potential and anti-AGEs activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available