Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer

Background: We aimed to investigate the impact of lymph node ratio (LNR, number of positive nodes/total number of excised nodes) on regional-only-failure, distant-only-failure and overall survival (OS) in oral squamous cell carcinoma (OSCC). Methods: Retrospective review of pN0-2 OSCC-patients (1994-2012) treated with curative-surgery with neck dissection postoperative radiotherapy (PORT) concurrent chemotherapy. LNR was subjected to multivariable analysis (MVA) of regional-only-failure, distant-only-failure and OS. Results: Overall 914 patients were identified; median follow-up: 51 months (1-189); pNO: 482 (52.7%), pNl: 128 (14%), pN2a: 6 (0.7%); pN2b: 225 (24.6%); pN2c: 73 (8%); median number of dissected nodes: 36 (6-125); median number of pN+: 2 (1-49); median LNR for pN+ patients: 6%; extranodal extension: 187 (20.5%). Bilateral neck dissection: 368 (40.3%); PORT: 452 (49.5%); and concurrent chemotherapy: 80 (8.8%). High grade, lymphovascular invasion perineural invasion and pT3-4 were associated with high LNR. On MVA, LNR was associated with regional-only-failure (HR = 1.06; 95%Cl: 1.04-1.08; p < 0.001), distant-only-failure (HR = 1.03; 95%Cl: 1.02-1.05; p = 0.004) and lower OS (HR = 1.03; 95%Cl: 1.02-1.05; p < 0.001). Similarly, in pN2-subgroup: LNR was associated with regional-only-failure (HR = 1.04; 95%Cl: 1.02-1.06; p < 0.001), distant-only-failure (HR = 1.03; 95%Cl: 1.01-1.06; p = 0.045) and lower OS (HR = 1.03; 95%Cl: 1.02-1.04; p < 0.001). Conclusion: High LNR is associated with higher regional-only-failure/distant-only-failure and lower OS. LNR should be assessed in future prospective trials for selection of adjuvant therapy. (C) 2017 Elsevier B.V. All rights reserved.