☆ 4.7 Article Proceedings Paper

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100 Gy/s

RADIOTHERAPY AND ONCOLOGY (2017)

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Journal

RADIOTHERAPY AND ONCOLOGY
Volume 124, Issue 3, Pages 365-369

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.radonc.2017.05.003

Keywords

Flash-RT; Whole brain irradiation; Cognition's preservation

Categories

Oncology Radiology, Nuclear Medicine & Medical Imaging

Funding

  1. Fond'action, Fond National Suisse de la Recherche Scientifique [31003A_156892]
  2. Lead Agency grant [FNS/ANR CR32I3L_156924]
  3. Ecole Normale Superieure de Cachan, France (MESR)
  4. Swiss National Science Foundation (SNF) [31003A_156892] Funding Source: Swiss National Science Foundation (SNF)

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This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100 Gy/s, whereas 10 Gy WBI at a conventional radiotherapy dose rate (0.1 Gy/s) totally impairs spatial memory. (C) 2017 Elsevier B.V. All rights reserved.

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