Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
Volume 9, Issue 3, Pages 1160-1166Publisher
INT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCH
DOI: 10.13040/IJPSR.0975-8232.9(3).1160-66
Keywords
Anticancer activity; DSC; Fourier Transform Infra-Red X-Ray Diffraction; Cytotoxicity; Spectroscopy; Silver nanoparticles
Categories
Ask authors/readers for more resources
In the proposed work, enhancement of anticancer potential of curcumin extracted from Curcuma longa Linn. by encapsulated in the silver nanoparticle. Curcumin was extracted from Curcuma longa by Soxhlet method. Curcumin is a kind of poly phenols which was widely used because of its medicinal application. Curcumin shows poor solubility and low absorption rate therefore its silver nanoparticles was formed to increase solubility, absorption as well as affectivity against tumor. Various analytical methods and assay such as Particle size, Zeta potential, Atomic Force Microscopy (AFM), Differential Scanning Colorimetric analysis (DSC), X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR), Drug Release, Hemolytic toxicity study and In-vitro cytotoxicity study were employed for monitoring the formation of nanoparticles. Presence of silver nanoparticles with an average size of 17.98 nm was revealed by Atomic Force Microscopy and particle size analyzer and zeta potential may obtained -4.68 mV. The result of hemolytic toxicity was demonstrated that Cur-AgNPs shows lesser hemotoxicity in comparison with plain curcumin and Cur-AgNPs were able to release 93.15% curcumin in 12 hrs whereas the plain curcumin was released 93.31% in 4 hrs. The crystalline nature of synthesized nanoparticles was done by X-ray diffraction. The results obtained by in-vitro cytotoxicity study, demonstrated that Cur-AgNPs cytotoxicity induced by curcumin to the tumor cells were dose dependent and had a greater cytotoxic effect on the tumor cells than plain curcumin. This work shows that curcumin encapsulated silver nanoparticles shows potential activity against cancer cell.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available