Journal
JOURNAL OF PEDIATRIC PSYCHOLOGY
Volume 43, Issue 2, Pages 122-132Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jpepsy/jsx090
Keywords
barriers; epilepsy; medication adherence; pediatric
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Funding
- National Institutes of Health [K23HD057333]
- National Institutes of Health (NICHD) [T32HD068223]
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Objective To determine the stability and influence of adherence barriers on medication adherence and seizure control in pediatric epilepsy. Methods Caregivers of 118 children aged 2-12 years old with epilepsy completed the Pediatric Epilepsy Medication Self-Management Questionnaire at nine time points over 2 years post diagnosis. Electronically monitored antiepileptic drug adherence and seizure outcome data were collected. Results Hierarchical linear modeling results for overall barriers remained stable over 2 years. Specific item-level barriers were also generally stable over time, with the exception of running out of medication becoming more of a barrier over time. No specific barriers were related to seizure control; however, difficulties swallowing medication, forgetting, and medication refusal were related to electronically monitored adherence over time. Conclusions Assessing for specific adherence barriers over time may lead to identification of interventions that result in improved adherence and care.
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