Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 46, Issue -, Pages 77-95Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20170044
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Funding
- National Institutes of Health, National Institute on Aging
- Fanconi Anemia Research Fund
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Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron-sulfur (Fe-S) helicase families are linked to hereditary disorders characterized by chromosomal instabilities, highlighting the importance of these enzymes. Moreover, mono-allelic RecQ and Fe-S helicase mutations are associated with a broad spectrum of cancers. This review will discuss and contrast the specialized molecular functions and biological roles of RecQ and Fe-S helicases in DNA repair, the replication stress response, and the regulation of gene expression, laying a foundation for continued research in these important areas of study.
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