Journal
ENVIRONMENTAL MICROBIOLOGY
Volume 17, Issue 11, Pages 4511-4526Publisher
WILEY
DOI: 10.1111/1462-2920.12915
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Funding
- Swedish Research Council for Medicine and Health [K2012-56X-22039-01-3]
- Carl Trygger Foundation [CTS 10:324]
- Karolinska Institutet
- National Research Foundation of Korea (NRF) [2012R1A1A2041712]
- KRIBB Research Initiative Program [KGM4611411]
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2014R1A6A3A03057742]
- National Research Foundation of Korea [2012R1A1A2041712] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Pseudomonas aeruginosa is a highly successful nosocomial pathogen capable of causing a wide variety of infectionswithclone C strains most prevalentworldwide. In this study, we initially characterize a molecular mechanism of survival unique to clone C strains. We identified aP.aeruginosa clone C-specific genomic island (PACGI-1) that contains the highly expressed small heat shock protein sHsp20c, the founding member of a novel subclass of class B bacterial small heat shock proteins. sHsp20c and adjacent gene products are involved in resistance against heat shock.Heat stable sHsp20c is unconventionally expressed in stationary phase in a wide temperature range from 20 to 42 degrees C. PurifiedsHsp20c has characteristic features of small heat shock protein class B as it is monodisperse, forms sphere-like 24-meric oligomers and exhibits significant chaperone activity. As theP.aeruginosaclone C population is significantly more heat shock resistant than genetically unrelated P.aeruginosa strains without sHsp20c, the horizontally acquired shsp20c operon might contribute to the survival of worldwide-distributed clone C strains.
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