Journal
CALCIFIED TISSUE INTERNATIONAL
Volume 102, Issue 5, Pages 512-521Publisher
SPRINGER
DOI: 10.1007/s00223-017-0321-0
Keywords
Estrogen; Sex steroids; Microbiota; Intestine; Bone loss; Probiotics; LGG; VSL#3 (TM)
Categories
Funding
- NIDDK NIH HHS [R01 DK108842, R01 DK112946, R01 DK119229, T32 DK108735] Funding Source: Medline
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Osteomicrobiology refers to the role of microbiota in bone health and the mechanisms by which the microbiota regulates post-natal skeletal development, bone aging, and pathologic bone loss. Here, we review recent reports linking gut microbiota to changes in bone phenotype. A pro-inflammatory cytokine milieu drives bone resorption in conditions such as sex steroid hormone deficiency. The response of the immune system to activation by the microbiome results in increased circulating osteoclastogenic cytokines in a T cell-dependent mechanism. Additionally, gut microbiota affect bone homeostasis through nutrient absorption, mediation of the IGF-1 pathway, and short chain fatty acid and metabolic products. Manipulation of microbiota through prebiotics or probiotics reduces inflammatory cytokine production, leading to changes in bone density. One mechanism of probiotic action is through upregulating tight junction proteins, increasing the strength of the gut epithelial layer, and leading to less antigen presentation and less activation of intestinal immune cells. Thus, prebiotics or probiotics may represent a future therapeutic avenue for ameliorating the risk of postmenopausal bone loss in humans.
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