Journal
JAPANESE DENTAL SCIENCE REVIEW
Volume 54, Issue 2, Pages 59-65Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jdsr.2017.11.004
Keywords
The junctional epithelium; Intraepithelial lymphocytes; ICAM-1; Cytokines; Chemokines; Enamel organ
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24592777, 15K11022]
- Grants-in-Aid for Scientific Research [15K11022, 24592777] Funding Source: KAKEN
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The continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of JE are maintained even in germfree condition. Therefore, the constitutive expression of adhesion molecules, cytokines, and chemokines might be used not only for anti-pathogenic defense but also for maintaining the physiological homeostasis of JE. In this review, we have mainly focused on the structural and functional features of JE, and discussed the function of intraepithelial lymphocytes in JE as a front-line anti-microbial defense barrier and regulator of JE hemostasis. (C) 2017 The Author. Published by Elsevier Ltd.
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