Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 187, Issue 5, Pages 933-940Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwx330
Keywords
Alzheimer dementia; cognitive aging; gene-environment interaction; omega-3 fatty acids
Categories
Funding
- Fondation pour la Recherche Medicale (FRM)
- Caisse Nationale Maladie des Travailleurs Salaries (CNAMTS)
- Direction Generale de la Sante (DGS)
- Mutuelle Generale de l'Education Nationale (MGEN)
- Institut de la Longevite
- Regional Council of Aquitaine
- Fondation de France
- Ministry of Research-INSERM Program Cohortes et collections de donnees biologiques
- ANR [2007LVIE 003]
- Fondation Plan Alzheimer
- Institut Pasteur de Lille
- Centre National de Genotypage
- US National Cancer Institute [P01 CA87969]
- Merck Research Laboratories
- US National Institutes of Health [HL043851, CA047988, HL080467, AG015933]
- Amgen
- National Institutes of Health [AG11101, AG13170, AG10161, R01AG031553, R01AG17917, RF1AG16819]
- Regional Council of Bourgogne
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Fish are a primary source of long-chain omega-3 fatty acids, which may help delay cognitive aging. We pooled participants from the French Three-City study and 4 US cohorts (Nurses' Health Study, Women's Health Study, Chicago Health and Aging Project, and Rush Memory and Aging Project) for whom diet and cognitive data were available (n = 23,688 white persons, aged >= 65 years, 88% female, baseline year range of 1992-1999, and median follow-up range of 3.9-9.1 years) to investigate the relationship of fish intake to cognitive decline and examine interactions with genes related to Alzheimer disease. We estimated cohort-specific associations between fish and change in composite scores of global cognition and episodic memory using linear mixed models, and we pooled results using inverse-variance weighted meta-analysis. In multivariate analyses, higher fish intake was associated with slower decline in both global cognition and memory (P for trend <= 0.031). Consuming >= 4 servings/week versus <1 serving/week of fish was associated with a lower rate of memory decline: 0.018 (95% confidence interval: 0.004, 0.032) standard units, an effect estimate equivalent to that found for 4 years of age. For global cognition, no comparisons of higher versus low fish intake reached statistical significance. In this meta-analysis, higher fish intake was associated with a lower rate of memory decline. We found no evidence of effect modification by genes associated with Alzheimer disease.
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