Journal
THERAPEUTIC DELIVERY
Volume 9, Issue 4, Pages 303-316Publisher
FUTURE SCI LTD
DOI: 10.4155/tde-2017-0113
Keywords
bio-hybrid micro-/nano-motors; cellular carriers; drug-delivery systems; micromotors; nanomotors; synthetic micro-/nano-motors
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Funding
- German Science Foundation [SPP 1726]
- Chinese Scholarship Council
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Micro-and nano-motors are emerging as novel drug delivery platforms, offering advantages such as rapid drug transport, high tissue penetration and motion controllability. They can be propelled and/or guided by endogenous (i.e., chemotaxis) or exogenous stimuli (e.g., ultrasound, magnetic fields, light) toward the area of interest. Moreover, such stimuli can be used to trigger the release of a therapeutic payload when the motor reaches certain location in order to improve the drug targeting. In this review article, we highlight medically oriented micro-/nano-motors, in particular the ones created for targeted drug delivery, and discuss their current limitations and possibilities toward in vivo applications.
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