Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 76, Issue 1-2, Pages 3-17Publisher
HUMANA PRESS INC
DOI: 10.1007/s12013-017-0811-8
Keywords
Dinitrosyl iron complexes; Nitrogen monoxide; Thiol-containing ligands; Living objects; EPR spectroscopy
Funding
- Russian Foundation of Basic Research [15-04-00708-a]
- Russian Scientific Foundation [16-13-10295]
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The overview demonstrates how the use of only one physico-chemical approach, viz., the electron paramagnetic resonance method, allowed detection and identification of dinitrosyl iron complexes with thiol-containing ligands in various animal and bacterial cells. These complexes are formed in biological objects in the paramagnetic (electron paramagnetic resonance-active) mononuclear and diamagnetic (electron paramagnetic resonance-silent) binuclear forms and control the activity of nitrogen monoxide, one of the most universal regulators of metabolic processes in the organism. The analysis of electronic and spatial structures of dinitrosyl iron complex sheds additional light on the mechanism whereby dinitrosyl iron complex with thiol-containing ligands function in human and animal cells as donors of nitrogen monoxide and its ionized form, viz., nitrosonium ions (NO+).
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