Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 266, Issue -, Pages 53-58Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2017.06.003
Keywords
NF1; BOLD; Pediatric; Brain training; Working memory; Regional homogeneity; Fractional amplitude of low frequency fluctuations
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Funding
- Children's Tumor Foundation (CTF) [2011-10-001]
- Jennifer and Daniel Gilbert Neurofibromatosis Institute at Children's National Health System
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In this pilot study, we examined training effects of a computerized working memory program on resting state functional magnetic resonance imaging (fMRI) measures in children with neurofibromatosis type 1 (NF1). We contrasted pre- with post-training resting state fMRI and cognitive measures from 16 participants (nine males; 11.1 +/- 2.3 years) with NF1 and documented working memory difficulties. Using non-parametric permutation test inference, we found significant regionally specific differences (family-wise error corrected) in two of four voxel-wise resting state measures: fractional amplitude of low frequency fluctuations (indexing peak-to-trough intensity of spontaneous oscillations) and regional homogeneity (indexing local intrinsic synchrony). Some cognitive task improvement was observed as well. These preliminary findings suggest that regionally specific changes in resting state fMRI indices may be associated with treatment-related cognitive amelioration in NFL Nevertheless, current results must be interpreted with caution pending independent controlled replication.
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