Journal
PSYCHIATRY RESEARCH
Volume 257, Issue -, Pages 497-500Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.08.022
Keywords
5hmC; 5mC; DNA modifications
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Funding
- National Natural Science Foundation of China [81371475]
- Guangdong Natural Science Foundation [2016A030310401]
- Guangdong Medical Research Foundation [A2016539]
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To improve understanding of DNA hydroxymethylation (5hmC) and methylation (5mC) in the development of schizophrenia, this study examined global 5hmC and 5mC levels in peripheral blood DNA of 264 patients with schizophrenia and 221 controls and observed increased 5mC levels in the patients and increased 5hmC levels in male patients but decreased levels in female patients as compared with the controls. The 5mC level displayed a gender-dependent positive correlation with age and the 5hmC level displayed a correlation with age positively in controls but negatively in patients, and their role in the pathogenesis of schizophrenia remains to be elucidated.
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