Journal
PSYCHIATRY RESEARCH
Volume 257, Issue -, Pages 296-302Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.07.069
Keywords
Depression; Memory biases; Electroconvulsive therapy
Categories
Funding
- National Nature Science Foundation of China [81471117, 81671354]
- National Basic Research Program of China [2015CB856400]
- National Key Technology Research and Development Program of the Ministry of Science and Technology of China [2015BAI13B01]
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Emotional memory bias is considered to be an important base of the etiology of depression and can be reversed by antidepressants via enhancing the memory for positive stimuli. Another antidepressant treatment, electroconvulsive therapy (ECT), has rapid antidepressant effect and frequently causes short-term memory impairment. However, it is unclear about the short-term effect of ECT on memory bias. In this study, the incidental memory task with emotional pictures were applied to evaluate the emotional memory of twenty depressed patients at pre and post-ECT (three days after ECT) compared to twenty healthy controls. The depressive symptoms were evaluated using the Hamilton rating scale of depression (HRSD). Before ECT, patients showed decreased recognition memory for positive pictures compared to controls and remembered negative pictures more easily than positive pictures in the recognition task. In patients, the main effect of session (pre-ECT and post-ECT) was significant for both recognition and recall memory with reduced memory performance. The interaction between valence (positive, neutral and negative) and session was significant for recognition memory, indicating that negative memory was impaired more severely than positive memory. Our study indicates that ECT relieves depressive symptoms and regulates emotional memory through more severe impairment on memory for negative stimuli.
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