Journal
PSYCHIATRY INVESTIGATION
Volume 14, Issue 4, Pages 471-482Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.4306/pi.2017.14.4.471
Keywords
Bipolar disorder; Depressive disorder; Major; Brain imaging/neuroimaging; Diffusion; Perfusion imaging
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Funding
- National Natural Science Foundation of China [81501456, 81471650]
- Natural Science Foundation of Guangdong Province, China [2014A030313375]
- Planned Science and Technology Project of Guangdong Province, China [2014B020212022]
- Planned Science and Technology Project of Guangzhou, China [1563000653]
- Fundamental Research Funds for the Central Universities, China [21615476]
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Objective Bipolar disorder (BD) is often misdiagnosed as unipolar depression (UD), leading to mistreatment and poor clinical outcomes. However, little is known about the similarities and differences in subcorticalgray matter regions between BD and UD. Methods Thirty-five BD patients, 30 UD patients and 40 healthy controls underwent diffusional kurtosis imaging (DKI) and three dimensional arterial spin labeling (3D ASL). The parameters including mean kurtosis (MK), axial kurtosis (Ka), radial kurtosis (Kr), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity (Dr) and cerebral blood flow (CBF) were measured by using regions-of-interest analysis in the caudate, putamen and thalamus of the subcortical gray matter regions. Results UD exhibited differences from controls for DKI measures and CBF in the left putamen and caudate. BD showed differences from controls for DKI measures in the left caudate. Additionally, BD showed lower Ka in right putamen, higher MD in right caudate compared with UD. Receiver operating characteristic analysis revealed the Kr of left caudate had the highest predictive power for distinguishing UD from controls. Conclusion The two disorders may have overlaps in microstructural abnormality in basal ganglia. The change of caudate may serve as a potential biomarker for UD.
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