Journal
PROTEOMICS CLINICAL APPLICATIONS
Volume 11, Issue 7-8, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.201600135
Keywords
Biomarker; Depletion; Enrichment; Fractionation; Plasma
Funding
- Faculty of Medicine Ramathibodi Hospital, Mahidol University [RF58047]
- International Health Policy Foundation, Ministry of Public Health, Thailand [IHPF59102559]
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Plasma is a rich source of biomarkers with clinical relevance. However, the wide dynamic range of protein concentration hinders the detection of low abundance proteins. Plasma prefractionation methods serve as indispensable tools to reduce plasma complexity, allowing the opportunity to explore tissue-derived proteins which leak into the circulation. This review summarizes common approaches in plasma prefractionation methods for proteomic analysis and then discusses some considerations in plasma prefractionation for clinical applications, reviewing some examples of its use in clinical situations.
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