Journal
PROTEOMICS
Volume 17, Issue 3-4, Pages -Publisher
WILEY
DOI: 10.1002/pmic.201600267
Keywords
Information theoretical approaches; Mass cytometry; Single cell barcode chip; Single cell data analysis; Single cell proteomics
Funding
- NIH/NCI [1U54 CA199090-01, 5U54 CA151819]
- Phelps Family Foundation
- Youth Program of the National 1000 Talents Project
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New insights on cellular heterogeneity in the last decade provoke the development of a variety of single cell omics tools at a lightning pace. The resultant high-dimensional single cell data generated by these tools require new theoretical approaches and analytical algorithms for effective visualization and interpretation. In this review, we briefly survey the state-of-the-art single cell proteomic tools with a particular focus on data acquisition and quantification, followed by an elaboration of a number of statistical and computational approaches developed to date for dissecting the high-dimensional single cell data. The underlying assumptions, unique features, and limitations of the analytical methods with the designated biological questions they seek to answer will be discussed. Particular attention will be given to those information theoretical approaches that are anchored in a set of first principles of physics and can yield detailed (and often surprising) predictions.
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