Journal
PROTEOMICS
Volume 18, Issue 10, Pages -Publisher
WILEY
DOI: 10.1002/pmic.201700038
Keywords
Peptide; Ribosome profiling; Small ORF; Translation; Upstream ORF
Funding
- NIH [R01-GM043778]
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation [GBMF3405]
- US Department of Agriculture-National Institute of Food and Agriculture Postdoctoral Fellowship [2016-67012-24720]
- NIFA [810713, 2016-67012-24720] Funding Source: Federal RePORTER
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Peptides encoded by small open reading frames (sORFs, usually <100 codons) play critical regulatory roles in plant development and environmental responses. Despite their importance, only a small number of these peptides have been identified and characterized. Genomic studies have revealed that many plant genomes contain thousands of possible sORFs, which could potentially encode small peptides. The challenge is to distinguish translated sORFs from nontranslated ones. Here, we highlight advances in methodologies for identifying these hidden sORFs in plant genomes, including ribosome profiling and proteomics. We also examine the evidence for new peptides arising from sORFs and discuss their functions in plant development, environmental responses, and translational control.
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