Journal
PROTEIN SCIENCE
Volume 27, Issue 1, Pages 245-258Publisher
WILEY
DOI: 10.1002/pro.3311
Keywords
integrative modeling; hybrid modeling; computational optimization; structural biology
Categories
Funding
- National Institutes of Health [R01 GM083960, P01 1AI091575I, P01 GM105537, P01 GM71790]
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Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (), and demonstrate its use.
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