Journal
PROTEIN AND PEPTIDE LETTERS
Volume 24, Issue 5, Pages 456-465Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866524666170120095128
Keywords
Antibody; bispecific antibody (BsAb); immunotherapeutic agent; cancer therapy; diabody; antitumor
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Antibodies have become the preferred therapeutic treatment option for cancers. Antibody therapy is associated with low toxic profile and specific in its activity, unlike chemotherapy and radiotherapy. Types of tumor are known to express multiple receptors that cross-talk to activate perpetual growth, proliferation and metastasis, and inhibit apoptosis in such tumors. Bispecific antibodies (BsAbs) are therefore the preferred agent for the treatment of such cancers due to its unique characteristics. This review discusses up to date therapeutic potentials of BsAbs.
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