Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 124, Issue -, Pages 1-10Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2017.08.001
Keywords
Docosahexaenoic acid; Brain development; Pregnancy; Breastfeeding; Neuroprotection; New dietary sources
Funding
- Department of Nutrition, Nutrition and Dietetics School, Faculty of Medicine, University of Chile
- Initiation FONDECYT (National Fund for Scientific and Technological Development) [11140174]
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Docosahexaenoic acid (C22: 6n-3, DHA) is a long-chain polyunsaturated fatty acid of marine origin fundamental for the formation and function of the nervous system, particularly the brain and the retina of humans. It has been proposed a remarkable role of DHA during human evolution, mainly on the growth and development of the brain. Currently, DHA is considered a critical nutrient during pregnancy and breastfeeding due their active participation in the development of the nervous system in early life. DHA and specifically one of its derivatives known as neuroprotectin D-1 (NPD-1), has neuroprotective properties against brain aging, neurodegenerative diseases and injury caused after brain ischemia-reperfusion episodes. This paper discusses the importance of DHA in the human brain given its relevance in the development of the tissue and as neuroprotective agent. It is also included a critical view about the ways to supply this noble fatty acid to the population.
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