Journal
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
Volume 11, Issue -, Pages 231-238Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CCID.S162724
Keywords
needle free; injector; jet injection; xylocaine; triamcinolone; PDT
Categories
Ask authors/readers for more resources
Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use. Methods: A review of the literature was performed with no limits placed on publication date. Results: Needleless injectors not only reduce pain during drug delivery but also confine the drug more evenly in the dermis. Understanding skin properties of the injection site is a key factor to obtain optimal results as well as setting the right parameters of the jet injector. Until the advent of disposable jet injectors/cartridges, autoclaving of the injector remains the only reliable method to eliminate the risk of infection. Needle-free intradermal injection using corticosteroids and/or local anesthetics is well documented with promising indications being developed. Limitations: Limitations of the review include low-quality evidence, small sample sizes, varying treatment parameters, and publication bias. Conclusion: New developments may help reconsider the use of jet injection technology. Future studies should focus on measurable optimized parameters to insure a safe and effective outcome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available