Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 136, Issue -, Pages 15-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2017.01.012
Keywords
Arachidonic acid; Essential fatty acids; Linoleic acid; Omega-3 blood biomarker; Omega-3; Omega-6; Eicosanoids
Funding
- Canada Research Chair in Nutritional Lipidomics [950-228125]
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Careful handling of data on fatty acid composition is needed when interpreting evidence for the influence of dietary n-3 and n-6 essential fatty acids on brain function and health conditions. The relative dietary supplies of competing n-3 and n-6 nutrients determine the balance of 20- and 22-carbon n-3 and n-6 highly unsaturated fatty acids (HUFA) which accumulate competitively at the 2-position of tissue phospholipids. In turn, the HUFA balance expressed as the %n-6 in HUFA affects the likely intensity of n-6 eicosanoid actions in diverse health conditions. As a result, measures of HUFA balance are important, valid biomarkers for designing and monitoring successful preventive nutrition interventions. Successful interventions must also consider the ability of fatty acid ligands to saturate binding sites of enzymes and receptors and give paradoxical dose response results.
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