Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 121, Issue -, Pages 30-39Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2017.06.002
Keywords
Cardiac muscle; Glucose metabolism; Dyslipidemia; Insulin resistance; Salvia hispanica L
Funding
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 945 BID OC/AR 2011]
- University of Litoral [CAI + D 0058 LI2012]
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This study reports the effects of dietary Salba (chia) seeds on the mechanisms underlying impaired glucose metabolism in the heart of dyslipemic insulin-resistant rats fed a sucrose-rich diet (SRD). Wistar rats were fed a SRD for 3 months. Afterwards, half the animals continued with the SRD; in the other half's diet chia seeds replaced corn oil (CO) for three months (SRD + chia). In the control group, corn starch replaced sucrose. The replacement of CO by chia seeds in the SRD restored the activities of key enzymes involved in heart glucose metabolism decreasing fatty acid oxidation. Chia seeds normalized insulin stimulated GLUT-4 transporter, the abundance of IRS-1 and pAMPK, changed the profile of fatty acid phospholipids, reduced left-ventricle collagen deposition and normalized hypertension and dyslipidemia. New evidence is provided concerning the effects of dietary chia seeds in improving the altered metabolic fate of glucose in the heart of dyslipemic insulin-resistant rats.
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