Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 126, Issue -, Pages 98-104Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2017.09.017
Keywords
Pro-resolving lipid mediator; Pregnancy; Fetal health; Omega-3 fatty acid; Docosahexaenoic acid; Resolvins
Funding
- National Institutes of Health [NIEHS K99ES025819]
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Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.
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